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Volume 4,Issue 2

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29 April 2025
Combination of Misoprostol and Oxytocin for Effective Control of Postpartum Hemorrhage During Cesarean Section
Yuling Guo
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1 Pingyu County Central Hospital, Zhumadian City 463000, Henan, China,
AOGR 2025 , 3(2), 48–54; https://doi.org/10.26689/aogr.v3i2.10374
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Objective: This study is to analyze the value of combining misoprostol and oxytocin in the prevention and control of postpartum hemorrhage during cesarean section. Methods: 82 cesarean section patients from July 2023 to July 2024 were selected as samples and randomly divided into two groups. Group A received misoprostol combined with oxytocin treatment, while Group B received only misoprostol treatment. The amount of postpartum hemorrhage, coagulation indicators, postpartum recovery indicators, and adverse reactions were compared between the two groups. Results: The intraoperative, 2-hour postpartum, 2-24-hour postpartum, and total blood loss in Group A were all lower than those in Group B (P < 0.05). The activated partial thromboplastin time (APTT), plasma prothrombin time (PT), fibrinogen (FIB), and thrombin time (TT) in Group A were all lower than those in Group B (P < 0.05). The first exhaust time, first time out of bed, and hospital stay after cesarean section in Group A were all shorter than those in Group B (P < 0.05). The adverse reaction rate in Group A was lower than that in Group B (P < 0.05). Conclusion: The application of misoprostol combined with oxytocin during cesarean section can optimize coagulation indicators, reduce blood loss, shorten postpartum recovery time, and is highly effective and feasible.

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