Association between FcγRIIB Gene Polymorphism, Periodontitis and Pregnancy-induced Hypertension in Chinese Pregnancy Women

Baiqiang Xu; Xiaonan Wang; Xiaoqing Wang; Junqiang Shan; Jiayu Fan; Peisong Meng; Cuiping Wang; Yanming Wang

doi:10.26689/aogr.v3i2.10494

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8 May 2025

Association between FcγRIIB Gene Polymorphism, Periodontitis and Pregnancy-induced Hypertension in Chinese Pregnancy Women

Baiqiang Xu, Xiaonan Wang, Xiaoqing Wang, Junqiang Shan, Jiayu Fan, Peisong Meng, Cuiping Wang, Yanming Wang

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¹ Department of Stomatology, The Forth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China,

² Department of Stomatology, Qingdao West Coast New District Hospital of Traditional Chinese Medicine, Qingdao 266427, Shandong, China,

AOGR 2025 , 3(2), 39–47; https://doi.org/10.26689/aogr.v3i2.10494

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

Objective: Research suggests a link between maternal periodontitis and pregnancy-induced hypertension (PIH). As an immunoglobulin G (IgG) receptor, FcγRIIB delivers inhibitory signals to B lymphocytes. Previous studies have demonstrated that FcγRIIB-232I/T polymorphism is associated with periodontitis, and the link between 232T allele carriers and periodontitis may stem from their reduced IgG antibody responses to P. gingivalis. The role of FcγRIIB-232I/T polymorphism in predisposing Chinese pregnant women to periodontitis and PIH was explored in this investigation. Methods: Clinical periodontal parameters and obstetric records were retrospectively analyzed in 87 Chinese pregnant women. FcγRIIB-232I/T genotyping was performed using genomic DNA isolated from peripheral blood samples from each participant. The expression levels of FcγRIIb on peripheral B lymphocytes from 10 women were measured by flow cytometry. Results: The FcγRIIB-232T allele was associated with elevated third-trimester blood pressure, with compounded effects observed in carriers concurrently affected by periodontitis. Periodontitis and PIH exhibited a shared genetic predisposition through the FcγRIIB-232I/T polymorphic locus. Among individuals carrying the FcγRIIB-232T allele, periodontitis was significantly associated with PIH. Conclusion: FcγRIIB-232T allele carriers of Chinese pregnancy women are more susceptible to periodontitis and PIH,and those with periodontitis are more susceptible to PIH.

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