Analysis and Research on the Effect of Isosorbide Mononitrate Combined with Nicorandil in the Treatment of Myocardial Ischemia in Coronary Heart Disease

Tianyu Zhou

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¹ Hailun People’s Hospital, Heilongjiang Province, Hailun 152300, Heilongjiang, China,

CR 2025 , 3(2), 42–48; https://doi.org/10.26689/cr.v3i2.10939

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

Objective: To study the efficacy of isosorbide mononitrate combined with nicorandil in the treatment of myocardial ischemia in coronary heart disease. Methods: 100 patients with myocardial ischemia due to coronary heart disease who visited our hospital from January 2022 to January 2025 were selected as samples and randomly divided into two groups. Group A received isosorbide mononitrate combined with nicorandil, while Group B received isosorbide mononitrate only. The efficacy, electrocardiogram, cardiac function, and complications were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B (P < 0.05). The electrocardiogram indicators of Group A were better than those of Group B (P < 0.05). The cardiac function indicators of Group A were better than those of Group B (P < 0.05). The complication rate of Group A was lower than that of Group B (P < 0.05). Conclusion: The combination of isosorbide mononitrate and nicorandil in the treatment of myocardial ischemia in coronary heart disease can improve cardiac function, reduce myocardial ischemia load, and is safe and efficient.

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