Based on the background of globalization, English education needs not only language skills training, but also the transmission and practice of the humanistic spirit. As the frontier of technological innovation, artificial intelligence, through its application in teaching, provides a brand-new perspective and tool for college English teaching, so as to ensure the development of teaching activities and formulate personalized teaching programs, so as to meet students’ diverse learning needs and realize the cultivation of a humanistic spirit. Personalized learning supported by artificial intelligence can provide one-to-one customized learning content for students with different levels and learning styles, and narrow individual differences. This study will explore how to effectively integrate artificial intelligence and humanistic spirit, so as to enhance the interest and depth of English learning and further transport talents with an international vision and humanistic care for society.