This paper studies the path and strategy of the integrated education of innovation and entrepreneurship education and ideological and political education in colleges and universities. Given the problems such as lack of integration opportunity, lack of pertinity and imperfect system guarantee, this paper puts forward the integration strategy with professional accomplishment as the guide, mass creation projects as the carrier and system optimization as the starting point, builds the education model of “value leading — ability training — quality improvement”, and creates the practice platform of “project guidance — school-enterprise collaboration — teachers and students co-creation.” The research shows that this model can effectively improve students’ innovative spirit, practical ability, and social responsibility and provide theoretical and practical support for college education reform and high-quality personnel training.