Objective: To study the method of improving the safety of the operating room, and to explore the application effect of detail management. Methods: The operating room of the hospital was used as a research object to study the effect of the operation room management in improving the safety of the operating room. In August 2016, the operation room was strengthened and the details of the operation room were collected. From June to August in 2016, the incidence of surgical accidents in the operating room [1] was compared with that of patients who underwent surgery between August and October, and the satisfaction of patients and their families for surgical care was compared. Results: The incidence of accidents in the operating room was significantly lower than that in August, which was significantly different from that before strength-ening the detailed management (P < 0.05). Conclusion: It is found that detailed management in the operating room has a positive effect on improving the safety of the operating room and can effectively reduce the accident rate in the operating room.