Objective: To evaluate the implementation effectiveness of standardized protective care procedures during hydrofluoric acid procedures in the dental department. Methods: This study was conducted from June 2023 to June 2025, selecting 90 patients who underwent hydrofluoric acid-related treatments in the outpatient dental department of this hospital during this period as subjects. Forty-five patients treated between June 2023 and June 2024 received conventional protective care (pre-intervention group), while 45 patients treated between June 2024 and June 2025 underwent the standardized protective care protocol (post-intervention group). Thirteen healthcare personnel participated in both pre- and post-intervention treatment phases. Based on the different nursing models, indicators such as the incidence of adverse events in patients and the exposure rate of healthcare personnel before and after implementation were compared to evaluate the effectiveness of the nursing intervention. Results: The incidence of oral mucosal irritation reactions in patients was lower after implementation, p < 0.05. Compared with the pre-implementation period, the incidence of procedure-related adverse events decreased after implementation, p < 0.05. There was a significant difference in the occupational exposure rate of healthcare personnel before and after implementation, with a higher rate observed before implementation (p < 0.05). Post-implementation, healthcare personnel achieved higher compliance scores for pre-procedure preparation, intra-procedure protection, and post-procedure handling (p < 0.05). Patient satisfaction with treatment was lower pre-implementation than post-implementation (p < 0.05). Conclusion: Adherence to standardized protective care procedures during hydrofluoric acid operations by dental department staff in outpatient settings standardizes practitioner techniques, effectively prevents oral mucosal irritation in patients, reduces occupational exposure risks for staff, minimizes adverse procedural events, and consequently enhances patient treatment satisfaction. This demonstrates significant practical value.