Objective: To explore the impact of high-quality nursing on the nursing effect of patients with hepatic encephalopathy, and provide a basis for optimizing clinical nursing plans. Methods: A total of 80 patients with hepatic encephalopathy admitted to a hospital from April 2023 to April 2024 were selected and randomly divided into a conventional group (37 cases, receiving conventional nursing) and an observation group (43 cases, receiving high-quality nursing) using a blind selection method. The incidence of complications, nursing satisfaction, changes in quality of life (SF-36 scale) and liver function indicators (ALT, AST, TBIL, ALB) before and after nursing were compared between the two groups. Results: The incidence of complications in the observation group (6.98%) was significantly lower than that in the conventional group (24.32%), and the nursing satisfaction (97.67%) was significantly higher than that in the conventional group (81.08), with statistically significant differences (p < 0.05); after nursing, the scores of each dimension and total score of the SF-36 scale, and the improvement range of liver function indicators in the observation group were significantly better than those in the conventional group, with statistically significant differences (p < 0.05). Conclusion: High-quality nursing can effectively reduce the risk of complications in patients with hepatic encephalopathy, improve nursing satisfaction and quality of life, and enhance liver function, which has important clinical promotion value.