Observation on the Efficacy of Non-Invasive Positive Pressure Ventilation in Respiratory Support Treatment for Severe Pneumonia

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO₂ and oxygenation index, significantly lower PaCO₂, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p < 0.05). Pre-treatment PaO₂, oxygenation index, PaCO₂, WBC, CRP, and PCT levels showed no significant differences between groups (p > 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.

References

Ma L, Liu G, Li Y, 2025, A Study on Noninvasive Positive Pressure Mechanical Ventilation Combined with Nasal High-Flow Oxygen Therapy for Severe Pneumonia with Respiratory Failure. Clinical Research, 33(10): 33–36.

Cui L, Zhang W, Liu S, 2025, Effects of Nebulized Ipratropium Bromide Combined with Non-Invasive Positive Pressure Ventilation on Oxygenation Status, APACHE II Score, and MODS Score in Patients with Severe Pneumonia and Respiratory Failure. Heilongjiang Medical Science, 48(8): 105–106.

Jin Y, Liu Y, Feng H, 2025, Efficacy Analysis of Nasal High-Flow Oxygen Therapy Combined with Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Chinese and Foreign Medical Research, 23(15): 27–30.

Liu X, Chen L, Chen M, 2025, Effect of BiPAP on Disease Control and Respiratory Function in Neonates with Severe Pneumonia. Medical Equipment, 38(3): 89–91 + 94.

Lü C, Chen S, 2025, Application of Risk Warning Intervention in ICU Patients with Severe Pneumonia Undergoing BiPAP. Medical Equipment, 38(3): 157–160.

Yuan G, Chen W, 2024, Clinical Outcomes of Alternating Nasal High-Flow Oxygen Therapy and Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Clinical Medical Research and Practice, 9(29): 63–66.

Zhao M, Song P, Wang Y, et al., 2024, Clinical Efficacy Study of “Alternating Mode of Non-Invasive Positive Pressure Ventilation + Ventilator Oxygen Therapy” in Elderly Patients with Severe Pneumonia and Respiratory Failure. Trauma and Critical Care Medicine, 12(2): 74–78.

Wang L, 2023, Comparative Efficacy of Warmed Humidified High-Flow Nasal Cannula Oxygen Therapy versus Non-Invasive Positive Pressure Ventilation in Patients with Severe Pneumonia and Type I Respiratory Failure. Chinese Journal of Public Health, 35(23): 165–167.

Song J, Wang N, Wang T, et al., 2023, Efficacy and Safety of High-Flow Oxygen Therapy Combined with Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Contemporary Chinese Medicine, 30(17): 44–48.

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