Lower limb fractures are common orthopedic injuries in clinical practice. Due to factors such as prolonged bed rest, immobilization, and vascular injury, patients are at a higher risk of developing deep vein thrombosis (DVT), which can lead to pulmonary embolism in severe cases, endangering their lives and affecting their prognosis and quality of life. Evidence-based nursing, guided by clinical problems, integrates high-quality clinical evidence, nursing expertise, and individual patient needs to develop scientific and standardized nursing plans, offering greater effectiveness compared to traditional empirical nursing. Evidence-based multidimensional nursing interventions break through the limitations of single nursing approaches by constructing a comprehensive prevention system from multiple dimensions, including physiology, medication, rehabilitation, psychology, and health education, precisely targeting the risk factors for DVT formation. This article reviews the implementation content of multidimensional nursing interventions for patients with lower limb fractures and analyzes their application effectiveness in DVT prevention, providing a reference for optimizing clinical DVT prevention nursing plans, improving nursing quality, and enhancing patient prognosis for those with lower limb fractures.