Nasopharyngeal carcinoma is one of the common malignant tumors in China. Due to its high sensitivity to nasopharyngeal carcinoma cells, radiotherapy has gradually become one of the preferred clinical treatment options. However, during radiotherapy, high-energy rays are highly likely to damage the normal skin tissue of patients, which not only aggravates patients’ pain and reduces their medical service experience, but also exerts a certain impact on the medical process and treatment effect. Multidisciplinary nursing can break the limitations of traditional nursing, integrate high-quality multidisciplinary resources, provide patients with more systematic and comprehensive nursing services, and plays an important role in improving radiation-induced skin damage. In this regard, this paper conducts an in-depth study on the impact of multidisciplinary nursing on radiation-induced skin damage in patients undergoing radiotherapy for nasopharyngeal carcinoma, aiming to provide some references for improving nursing quality and promoting clinical nursing reform.