ARTICLE
Volume 10,Issue 7
30 June 2026
Effects of Different Extraction Processes on the Anti-Tumor Activity of Phellinus linteus
Cong Min ,
Shenghua Wu ,
Rongxiang Wang ,
Zhaoyan Wei
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1
Shaanxi University of Technology, Hantai District, Hanzhong 723000, Shaanxi, China,
2
Linqing Qingyuan Zhengben Biomedical Techn ology Co., Ltd., Linqing 252600, Shandong, China,
JCNR 2026 , 10(6), 53–58;
https://doi.org/10.26689/jcnr.v10i6.15544
© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Phellinus linteus is a traditional medicinal fungus in China, mainly including four common species with a long medicinal history. Modern pharmacology has confirmed that Phellinus linteus exhibits significant anti-tumor activity, and its core active components include polysaccharides, polyphenols, and terpenoids. The extraction process of Phellinus linteus greatly affects the dissolution, structural integrity, and anti-tumor activity of its active components. Different processes may lead to significant differences in the activity of extracts due to variations in their principles and operations. In view of this, this paper analyzes the effects of different extraction processes on the anti-tumor activity of Phellinus linteus, and proposes some prospects for optimization directions and application prospects, so as to provide references for the extraction of active components from Phellinus linteus.
References
Sun K, Liu X, Jin X, et al., 2024, Research Progress on Anti-Tumor Active Components and Their Mechanisms of Action of Phellinus igniarius. Progress in Biotechnology, 14(06): 929–936.
Yang Y, Lei X, Xie L, et al., 2024, Optimization of Co-Fermentation Process of Inonotus hispidus and Phellinus vaninii and Analysis of Anti-Tumor Activity of Exopolysaccharides. Edible Fungi of China, 43(03): 78–85 + 106.
Ge J, 2024, Isolation, Purification, and Heterologous Expression of Anti-Tumor Active Proteins from Phellinus linteus Mycelium, thesis, Huazhong Agricultural University.
Su C, Yang Z, Ye L, et al., 2023, Microbial Exogenous Induction of Polysaccharide Synthesis in Poria cocos Mycelium. Proceedings of the 12th Academic Seminar on Medicinal Fungi: 102.
Liu J, Wei B, Bi W, et al., 2023, Chemical Constituents and Anti-Tumor Activity of the Mycelium of Phellinus linteus-Kelp Two-Way Fermentation. Food Research and Development, 44(19): 61–67.
Wei B, Liu J, Bi W, et al., 2023, Optimization of Liquid Fermentation Process and In Vitro Anti-Tumor Activity of Medicinal Fungus Phellinus linteus. Biochemical Engineering, 9(04): 19–25.
Li Y, Li F, Yang X, et al., 2023, Isolation, Purification, Antioxidant and Anti-Tumor Activity Analysis of Polysaccharides from Phellinus linteus Mycelium. Science and Technology of Food Industry, 44(11): 127–135.
Zhang J, 2022, Comparative Study on Immunomodulatory and In Vitro Anti-Tumor Activities of Phellinus linteus From Different Varieties and Cultivation Methods, thesis, Anhui Medical University.
Hou Y, Ma J, Li N, 2022, Effects of Different Origins, Cultivation Modes and Substrates on the Content of Main Components and In Vitro Anti-Tumor Activity of Phellinus linteus. Journal of Chinese Medicinal Materials, 45(03): 536–541.
Yang Y, 2021, Study on Anti-Tumor Effects and Mechanisms of Total Extracts from Phellinus linteus and Its Active Monomer Osmundacetone, thesis, Anhui Medical University.
He P, Yang Y, Di L, et al., 2020, Comparative Study on In Vitro Anti-Tumor Activity of Medicinal Phellinus baumii Cultivated on Different Substrates. Mycosystema, 39(07): 1400–1409.
Huang L, An C, Liu D, et al., 2019, Effects of Total Flavonoids from Liquid-Fermented Phellinus linteus on Anti-Tumor Activity and Cell Cycle. Journal of Shandong University of Technology (Natural Science Edition), 33(02): 65–68 + 73.
Wu X, Wang C, Bao H, 2018, Study on Anti-Tumor Activity of Aqueous Extracts from Different “Phellinus linteus”-Like Fungi. Biotechnology Bulletin, 34(08): 138–143.
Lü H, 2018, Comparative Study on Anti-Tumor Activities of Polysaccharides and Flavonoids from Phellinus linteus. China Journal of Chinese Materia Medica, 33(01): 27–29.
Ying R, Wu C, Huang M, et al., 2017, Study on Anti-Tumor Activity of Polysaccharides from Fruiting Bodies and Mycelia of Phellinus linteus. China Food Additives, 2017(12): 57–61.
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