Objective: To investigate the clinical efficacy of orthodontic treatment for anterior tooth displacement caused by periodontitis. Methods: Seventy patients with anterior tooth displacement caused by periodontitis admitted to our hospital from October 2021 to February 2024 were randomly divided into a control group and an observation group, with 35 cases in each group. The control group received basic periodontal treatment, while the observation group received orthodontic treatment. The pain level, tooth function, periodontal condition, and inflammatory factor levels of the two groups were compared before and after treatment. Results: The pain level of the observation group after treatment was significantly lower than that of the control group (P < 0.05); tooth function was significantly better than the control group (P < 0.05); the height of anterior alveolar bone and the depth of periodontal pocket were both lower than the control group (P < 0.05); and the level of inflammatory factors was lower than the control group (P < 0.05). Conclusion: Orthodontic treatment for anterior tooth displacement caused by periodontitis is effective and can significantly improve patients' tooth function and periodontal condition, reduce pain, and lower inflammatory response, with high clinical application value.