Objective: To analyze the application value of artificial intelligence (AI) in the comprehensive service pathway for rational clinical use of western medicines. Methods: A sample of 73 patients undergoing western medicine treatment from December 2024 to March 2025 was selected and divided into groups by lottery. Group A received AI-assisted management for rational clinical use of western medicines, while Group B received conventional management. Thirty-six patients taking oral western medicines were included in Group B. Results: Group A outperformed Group B in terms of the irrationality rate of western medicine usage, drug management scores, adverse reaction rates, complaint rates, and satisfaction levels, with p < 0.05. Conclusion: AI-assisted rational clinical use of western medicines enhances drug management quality, reduces the irrationality rate of medication usage, and decreases complaint rates related to western medicine usage.