Objective: Understand the level of anxiety and depression of PD caregivers, and pay attention to the relationship between mental health and different genders. Methods: 200 PD patients and their caregivers were recruited. The Hamilton Anxiety Scale (HAMA) and the 17-item Hamilton Depression Scale (HAMD) were used to assess the anxiety and depression of the patients; The Mental Component Summary scale (MCS) of the SF-36 was used to test the mental health status of PD caregivers. Results: The PD caregivers HAMA detection of anxiety was 59 cases (29.5%), including 44 female caregivers and 15 males anxious; the PD caregivers HAMD detection of depression was 96 cases (48.0%), including 66 female caregivers and 30 male caregivers; the MCS score of PD male caregivers was 47 (42.75–52.25), and the MCS score of PD female caregivers was 41 (39–48). There were statistically significant differences in anxiety, depression and mental health scores among caregivers of different genders (p < 0.05). Conclusion: The anxiety, depression and mental health of PD female caregivers were worse than male caregivers. Clinical and social work need to pay more attention to the caregivers with mental health.