Objective: To investigate the effects of intraspinal anesthesia combined with acupoint injection at Zusanli (ST36) and Sanyinjiao (SP6) on labor progression and delivery outcomes in full-term primiparas. Methods: A retrospective analysis was conducted on 303 full-term primiparas who delivered between July and December 2023. According to the analgesic method, the participants were divided into an observation group (n = 110) and a control group (n = 193). Maternal general characteristics, mode of delivery, duration of each labor stage, incidences of uterine inertia, urinary retention, and intrapartum fever, as well as neonatal outcomes, were compared between the two groups. Results: The rate of vaginal delivery in the observation group was significantly higher than that in the control group (p < 0.05). The duration of the first stage of labor was significantly shorter (p < 0.05). The incidences of uterine inertia and urinary retention were both significantly lower in the observation group than in the control group (p < 0.05). There were no significant differences in neonatal Apgar scores or neonatal intensive care unit (NICU) transfer rates between the two groups (p > 0.05). Conclusion: Intraspinal anesthesia combined with acupoint injection at Zusanli and Sanyinjiao can increase the rate of vaginal delivery, shorten the first stage of labor, and reduce obstetric interventions in full-term primiparas, without increasing adverse maternal or neonatal outcomes.