ARTICLE
Volume 10,Issue 7
31 December 2025
Pathogenesis of Hyaline Membrane Disease in Newborns and Advances in Non-invasive Ventilation Therapy
Ying Guo ,
Jijing Han
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1
Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China,
JCNR 2025 , 9(12), 413–419;
https://doi.org/10.26689/jcnr.v9i12.13259
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Hyaline Membrane Disease (HMD) in newborns, also known as neonatal respiratory distress syndrome, is a common critical illness in premature infants, with an incidence inversely correlated with gestational age, posing a serious threat to the life and health of newborns. This paper systematically reviews the core pathogenesis of HMD, focusing on the abnormal metabolism of pulmonary surfactant (PS), genetic factors, immature lung development, and the synergistic effects of inflammatory oxidative stress. It highlights the advances in non-invasive ventilation (NIV) therapy for HMD, including the mechanisms of action, clinical application effects, and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation (NCPAP), nasal intermittent positive pressure ventilation (NIPPV), and heated humidified high-flow nasal cannula ventilation (HHHFNC). The aim is to provide references for standardized clinical treatment.
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