As an important branch of traditional medicine, Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment, with significant therapeutic effects and widespread popularity. This article introduces Professor Fang Gang’s experience in treating obesity-type polycystic ovary syndrome (PCOS) with modified Zhuang Medicine Mao Xia Yin. Professor Fang Gang proposes that the etiology and pathogenesis of obesity-type polycystic ovary syndrome (PCOS) primarily stem from spleen deficiency, which impairs the transport of water and dampness. This dysfunction leads to the accumulation of dampness that transforms into phlegm. Over time, the stagnation of phlegm and dampness generates internal heat, resulting in the formation of “dampness toxin,” “phlegm toxin,” and “heat toxin.” These pathological toxins obstruct the circulation of Qi and blood, causing stasis and the emergence of “stasis toxin.” The buildup of these toxins ultimately blocks the three channels and two pathways, disrupting the harmony among the three Qi of heaven, earth, and man. This disharmony culminates in impaired uterine gland function. Therefore, the treatment mainly focuses on tonifying deficiency, detoxifying, and regulating Qi.