Objective: To evaluate the value of humanistic nursing care during pediatric nebulization treatment. Methods: From January 2024 to June 2024, 250 pediatric patients receiving nebulization treatment were given routine care and included in the control group. From July 2024 to December 2024, 250 pediatric patients receiving nebulization treatment were given full humanistic care by nurses and included in the observation group. The differences in patient compliance, symptom resolution time, parental satisfaction, and emotional scores were compared. Results: The compliance of pediatric nebulization patients in the observation group was higher than that in the control group (P < 0.05). The disappearance time of inflammation, cough, expectoration, fever, and hospital stay in the observation group were shorter than those in the control group (P < 0.05). Parental satisfaction with pediatric nebulization in the observation group was higher than that in the control group (P < 0.05). The scores of anxiety (SAS) and depression (SDS) among parents of pediatric nebulization patients in the observation group were lower than those in the control group (P < 0.05). Conclusion: The application of nurses’ full humanistic care in pediatric nebulization treatment can promote the resolution of respiratory system symptoms, optimize patients’ lung function, improve patient cooperation, and is highly effective and feasible.