Pharmacological Study of Azithromycin Combined with Cephalosporins in the Treatment of AECOPD

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Abstract

Objective: To analyze the efficacy of azithromycin combined with cephalosporins in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 62 AECOPD patients who visited the hospital from January 2024 to December 2024 were selected as samples and randomly divided into two groups using the lottery method. Group A was treated with azithromycin and cephalosporins, while Group B was treated with cephalosporins only. The efficacy, lung function, inflammatory factors, and adverse reactions were compared between the two groups. Results: The efficacy of AECOPD treatment in Group A was higher than that in Group B (P < 0.05). The forced vital capacity (FVC), peak expiratory flow (PEF), and forced expiratory volume in 1 second (FEV1) in Group A were all higher than those in Group B (P < 0.05). The levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in Group A were all lower than those in Group B (P < 0.05). Conclusion: The combination of azithromycin and cephalosporins in the treatment of AECOPD can inhibit inflammatory factors and improve lung function, with safety and high efficiency.

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