The Impact of Timing of Laparoscopic Cholecystectomy after Percutaneous Transhepatic Gallbladder Drainage on the Final Therapeutic Effect in Patients with Acute Calculous Cholecystitis

Yunguang Nan, Jianbo Zhang, Wei Liu, Bo Jiang, Yawei Ding, Chang Shu

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¹ Shuyang Benevolent Hospital,

OTD 2025 , 3(2), 1–7; https://doi.org/10.26689/otd.v3i2.10536

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

Objective: To explore the therapeutic effect of laparoscopic cholecystectomy (LC) after percutaneous transhepatic gallbladder drainage (PTGBD) in the treatment of acute calculous cholecystitis (ACC). Methods: A total of 50 ACC patients treated from January 2022 to January 2025 were selected as samples and randomly divided into two groups. Group A received LC after PTGBD, while Group B received LC only. Surgical indicators, inflammatory factors, liver function indicators, complications, and conversion to open surgery rates were compared between the two groups. Results: The operation time, postoperative abdominal drainage time, postoperative anal exhaust time, and hospital stay in Group A were shorter than those in Group B, and the intraoperative blood loss was lower than that in Group B (P < 0.05). The levels of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in Group A were lower than those in Group B (P < 0.05). The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBiL), and amylase (AMY) in Group A were lower than those in Group B (P < 0.05). The complication rate and conversion to open surgery rate in Group A were lower than those in Group B (P < 0.05). Conclusion: LC after PTGBD for the treatment of ACC can accelerate postoperative recovery, inhibit inflammatory factors, improve liver function, and is safe and efficient.

References

Duan R, Li S, 2021, Effects of Percutaneous Transhepatic Gallbladder Puncture and Drainage Combined With Sequential Laparoscopic Cholecystectomy on Trauma Stress and Energy Metabolism in Elderly Patients With Acute Cholecystitis. Chinese Journal of Geriatrics, 41(23): 5210–5213.

Lin J, Liu B, 2016, Abstract Translation of “2016 World Emergency Surgery Association Guidelines for Acute Calculous Cholecystitis”. Journal of Clinical Hepatology, 32(10): 1843–1846.

He L, 2023, Clinical Study of Delayed Laparoscopic Cholecystectomy After Percutaneous Transhepatic Gallbladder Puncture and Drainage for Acute Calculous Cholecystitis in the Elderly. Henan Journal of Surgery, 29(6): 98–101.

Dai X, Liu R, 2023, Clinical Efficacy of CT-Guided Percutaneous Transhepatic Gallbladder Puncture and Catheter Drainage Combined With Laparoscopic Cholecystectomy for Acute Calculous Obstructive Cholecystitis. Guizhou Medicine, 47(3): 436–437.

Zhou Z, Mei Y, Yang X, et al., 2019, Study on the Short-Term Efficacy of Percutaneous Transhepatic Gallbladder Puncture and Drainage Combined With Delayed Cholecystectomy in the Treatment of Acute Cholecystitis. Journal of Practical Hepatology, 22(4): 597–600.

Hai Y, Wang Y, Fang X, et al., 2022, Comparative Study on the Efficacy and Safety of Initial or Later Percutaneous Gallbladder Puncture and Drainage Combined With Sequential Laparoscopic Cholecystectomy in the Treatment of Acute Cholecystitis. Journal of Practical Hepatology, 25(1): 124–127.

Feng J, 2018, Observation on the Efficacy of Percutaneous Transhepatic Gallbladder Puncture and Drainage Combined With Laparoscopic Cholecystectomy in the Treatment of Acute Cholecystitis. Modern Diagnosis and Treatment, 29(23): 3855–3856.

Zhu X, Zhu X, Feng H, 2019, Timing Selection of Laparoscopic Cholecystectomy After Percutaneous Transhepatic Gallbladder Puncture and Drainage for Acute Suppurative Cholecystitis. Journal of Practical Clinical Medicine, 23(19): 73–75.

Lu M, Su W, Zhao R, et al., 2024, Efficacy Analysis of Early Laparoscopic Cholecystectomy After Percutaneous Transhepatic Gallbladder Drainage for Gallbladder Stones With Acute Cholecystitis With Onset Time >72 Hours. Chinese Journal of Modern General Surgery Progress, 27(8): 639–641.

Liu J, 2020, Observation on Laparoscopic Cholecystectomy After Percutaneous Transhepatic Gallbladder Puncture and Catheter Drainage in the Treatment of Acute Suppurative Cholecystitis in the Elderly. Jiangxi Medical Journal, 55(8): 1042–1043.

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