The Mechanisms and Research Progress of Chinese Medicine Monomers in Reversing Chemotherapy Resistance in Ovarian Cancer

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

The development of chemotherapy resistance is a critical factor leading to treatment failure and high mortality in ovarian cancer. Among current research directions, Chinese medicine monomers (CMMs) have shown great potential in reversing chemotherapy resistance due to their multi‑targeting properties and low toxicity. This review summarizes the research progress of various Chinese medicine monomers in reversing chemotherapy resistance in ovarian cancer, including polyphenols (such as quercetin, curcumin, epigallocatechin‑3‑gallate, resveratrol, kaempferol, myricetin, and ellagic acid), alkaloids (such as berberine, piperine, sanguinarine, and capsaicin), terpenoids (such as toosendanin and triptolide), and phenylpropanoids (such as myristicin and apiole). These monomers primarily exert their effects by regulating key signaling pathways (including PI3K/AKT/mTOR, p53, and NF-κB) and by interfering with critical processes such as drug efflux, DNA damage repair, apoptosis, and autophagy, thereby enhancing the sensitivity of ovarian cancer cells to chemotherapeutic agents like cisplatin. Furthermore, this review discusses the advantages of combination strategies involving Chinese medicine monomers, as well as the current challenges.

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