Clinical Efficacy of Modified Gegen Qinlian Decoction Combined with Probiotics in Treating Radiation Enteritis and Its Regulatory Effect on Intestinal Flora

Xiaofeng Miao, Tong Wei, Haichao Guan, Yufan Zhang, Xiaoqin Guo, Ke Zhao, Xin Zhao, Rongrong Chai, Junsuo Duan, Rui Shi, Yanming Zhang

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¹ Linfen Central Hospital, Linfen 041000, Shanxi, China,

² Changzhi Medical College, Changzhi 046000, Shanxi, China,

PAR 2025 , 9(6), 96–103; https://doi.org/10.26689/par.v9i6.12910

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

Objective: To investigate the clinical efficacy of Modified Gegen Qinlian Decoction combined with probiotics (Clostridium butyricum live capsules) in treating radiation enteritis (RE) in tumor patients, as well as its regulatory effect on the structure of intestinal flora, providing clinical evidence for the integrated traditional Chinese and Western medicine treatment of radiation enteritis. Methods: A total of 40 patients with radiation enteritis admitted to the Oncology Department of Linfen Central Hospital from September 2023 to December 2024 were selected and divided into an observation group and a control group according to the random number table method, with 20 cases in each group. The control group was treated with Clostridium butyricum live capsules, while the observation group was treated with Modified Gegen Qinlian Decoction in addition to the treatment given to the control group. Both groups received a 4-week treatment course. Intestinal function indicators and changes in intestinal flora structure were compared between the two groups before and after treatment, and clinical efficacy was evaluated. Results: After 4 weeks of treatment, the total effective rate in the observation group versus the control group was (95.00% vs 65.00%), with a statistically significant difference (P < 0.05). The fecal formation rate in the observation group (85.00% vs 60.00%) was significantly higher than that in the control group, and the defecation frequency (2.15 ± 0.42 vs 3.85 ± 0.65) times/day was significantly lower than that in the control group, with statistically significant differences (P < 0.05). After treatment, the quantities of Bifidobacterium (6.85 ± 0.72 L vs 5.23 ± 0.61 L) gCFU/g and Lactobacillus (6.52 ± 0.68 L vs 4.98 ± 0.57 L) gCFU/g in the observation group were significantly higher than those in the control group, while the quantities of Escherichia coli (4.12 ± 0.53 L vs 5.67 ± 0.65 L) gCFU/g and Staphylococcus (3.85 ± 0.48 L vs 5.23 ± 0.59 L) gCFU/g were significantly lower than those in the control group, with statistically significant differences (P < 0.05). Conclusion: Clinical studies have confirmed that the synergistic treatment of radiation enteritis with Modified Gegen Qinlian Decoction and probiotics can significantly improve patients’ clinical symptoms and restore the balance of intestinal flora, providing an effective regimen for clinical treatment.

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