ARTICLE
Volume 10,Issue 4
10 December 2025
Mechanism of Hedysarum Multijugum Maxim. in Treatment of Bladder Cancer Based on Network Pharmacology and Molecular Docking Technology
Hong Tian ,
Yunchen Zhang ,
Yang Hu ,
Chong Yun Xuan ,
Liquan Sun ,
Hao Gu
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1
School of Life Science, Beijing Institute of Technology, Beijing 100081, China,
2
XUTELI School, Beijing Institute of Technology, Beijing 100081, China,
3
School of Computer Science & Technology, Beijing Institute of Technology, Beijing 100081, China,
PAR 2025 , 9(6), 17–23;
https://doi.org/10.26689/par.v9i6.13003
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
To investigate the targets and mechanism of Hedysarum Multijugum Maxim (HMM) in treatment of bladder cancer (BC). Based on Traditional Chinese Medicine Systems Pharmacology (TCMSP) and gene databases, active substances and potential targets of HMM were screened, and the HMM-active substances-targets-BC (HATB) regulatory network and PPI network were constructed. Hub targets were screened by Cytoscape. The main active substances and Hub targets were molecularly docked with AutoDock and visualized by PyMOL. 12 Hub targets were screened. Molecular docking showed that active substances mainly acted on MAPK14, MAPK1 and CCND1. The bindings of calycosin to MAPK14, formononetin to MAPK14, and calycosin to CCND1 were stable.
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