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Volume 4,Issue 2

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31 December 2025
Analysis of Differences in Urine Concentration Function and Erythrocyte Membrane Permeability among Different Animal Species
Changjie Chen ,  Lifeng Liu
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1 The Affiliated Hospital of Beihua University, Jilin City 132001, Jilin Province, China,
2 School of Basic Medical Sciences, Beihua University, Jilin City 132013, Jilin Province, China,
UR 2025 , 3(4), 16–21; https://doi.org/10.26689/ur.v3i4.13539
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Through comparative studies on renal structure and urine concentration function, this research aims to observe and analyze the differential mechanisms among different animal species. Using rats as the research subjects and employing a high-protein feeding method, the study explores the mechanism of urea’s effect on urine concentration function from multiple levels, including gene expression regulation and protein levels. Erythrocyte membrane permeability tests are conducted to compare the degree of differences among various animal species. This study utilized experimental techniques such as RT-PCR, Western-blot, Stopped-flow, and immunohistochemistry to investigate the urine concentration mechanism at the cellular, tissue, and whole-organism levels, laying a foundation for further screening and preparing animal models for studying the urine concentration mechanism.

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