As a basic component of college education and teaching system, English teaching quality is a key factor affecting the improvement and development of college students’ communicative literacy. With the development of globalization, the universal value of the English language becomes increasingly prominent, and the cultural collision between countries becomes more intense. In this context, it is of great significance to improve students’ language application skills by deepening the reform of college English teaching. This can encourage colleges and universities to change the previous teaching concept centered on language knowledge systems and guide students to break traditional thinking patterns in innovative classroom learning and practice, so as to form a good cross-cultural communication awareness, behavior, and ability. Based on this, this paper highlights the necessity of college English teaching reform from the perspective of intercultural communication and the practical problems faced by English teaching reform and discusses the practical path of cultivating college students’ intercultural communication competence.