In the new era, the “accurate thinking and politics” of adhering to accurate thinking, carrying out accurate service and realizing accurate education has become a new form of ideological and political education, and also marks a new direction for the in-depth cultivation of psychological education in colleges and universities. With the rapid economic and social development, the social environment is constantly changing, and the educational reform advocated cannot keep up with the rapid development of the era, leading to the increasing prominence of students‘ mental health problems ^[1]. The promotion of students’ physical and mental health has become a common concern of schools and parents. In this subject, the home-school cooperative education of college students‘ mental health is based on the trend and gives policies in accordance with the time, and draws wisdom supply from the theory of “precise thinking and politics”, which is of great significance to meet the practical demand of college students‘ mental health educators for school-school cooperative education mechanism ^[2]. This paper aims to investigate and analyze the current status and existing problems of the home-school collaborative education mechanism for mental health of college students, and innovatively propose the “85421” home-school collaborative education mechanism, with the purpose of improving students’ comprehensive literacy and helping them establish a correct outlook on life and values to lay a solid foundation for their future development in society ^[3].