In the era of “Internet +”, micro-courses have injected vitality into the teaching reform of organic chemistry courses in colleges and universities, which not only promotes the sharing of high-quality Internet education resources and the connection of industry and teaching content, but also optimizes the connection of teaching inside and outside the class to meet the personalized learning needs of students, so as to improve the quality of teaching. This paper expounds the necessity of developing organic chemistry micro-courses under the cloud platform, clarifies the principles for the development of organic chemistry micro-courses, and proposes to explain the cutting-edge scientific research results of the industry in micro-courses, record the organic chemistry experiment micro-courses, establish the micro-course resource base and collect the cloud platform micro-course data, in order to improve the development and application quality of undergraduate organic chemistry micro-courses.