With the rapid development of the cultural industry, the demand for talents in the music performance industry has shown a trend of diversification, skill-orientation and professionalism. Against this background, the music performance major in higher vocational colleges is in urgent need of innovating its education and teaching model and talent cultivation path, to further strengthen the connection between the talent “cultivation chain” and the “demand chain”, and cultivate more high-quality music performance professionals for society. As a characteristic model of talent cultivation in vocational education, school-enterprise cooperation can effectively strengthen the connection and matching between the cultivation of music performance professionals and social talent demand, and is of great value in solving the current contradiction between supply and demand of music performance professionals. This paper discusses the value and significance of the school-enterprise cooperation talent cultivation model, and explores the practical paths of the model for the music performance major in higher vocational colleges, for reference only.