With the rapid development of digital technology, the digitalization of education is continuously promoted in depth. As an important base for cultivating high-quality technical and skilled talents, vocational education needs to keep up with the trend of the times to adjust teaching. Teachers’ information-based teaching ability has become a key indicator to measure the teaching quality of vocational education and promote the high-quality development of vocational education. As a new teaching mode that deeply integrates technology and teaching, the TPACK framework can further improve the information-based teaching ability of vocational college teachers. Starting from the connotation of the TPACK framework, this paper deeply analyzes the importance of improving the information-based teaching ability of vocational college teachers based on the TPACK framework under the background of digital-intelligent empowerment, and systematically discusses the effective paths to improve it. It is expected to provide new ideas for the professional development of vocational college teachers.