As a new teaching mode, although mixed teaching is widely used in the teaching reform of higher vocational colleges, it is still faced with problems such as poor control of online learning schedule, disconnection between online and offline teaching, insufficient teaching resources and platform construction, lack of teachers mixed teaching ability and imperfect evaluation system. In order to promote the teaching reform of nursing courses in higher vocational colleges, this study puts forward measures such as improving students independent learning ability, strengthening the connection between online and offline teaching, optimizing the construction of teaching platforms and resources, strengthening teacher training and improving the evaluation system.