In recent years, China’s science and technology have been developing rapidly, and network technology has also been continuously optimized. Against this backdrop, the academic administration work of secondary colleges in universities has ushered in more opportunities, but also challenges. The development of information technology plays an important role in the work of academic administrators in secondary colleges, enabling them to change their thinking modes and strive to innovate academic administration work. Currently, however, academic administrators have not yet fully adapted to the informatization background, and some problems still need to be solved. This paper first analyzes the significance of improving the work efficiency of academic administrators in secondary colleges of universities under the background of informatization, then summarizes the existing problems, and finally puts forward specific strategies for improving their work efficiency under this background, for reference.