With the rapid development of new media technology, its application value in the field of education models can hardly meet the diverse needs of contemporary college students. How to give full play to the advantages of new college students’ mental health education has become increasingly prominent. Facing the new situation and tasks of mental health education in the new media era, traditional mental health media and innovating the content and forms of mental health education have become a major and urgent issue for educators. Based on this, this paper studies the application of college students’ mental health education from the perspective of new media, expounds the positive empowering role of college students’ mental health education in the new media era, and proposes targeted application strategies, aiming to provide theoretical reference and practical guidance for optimizing the mental health education model for college students in the new media era.