With the deepening of educational reform, off-campus practical teaching bases in vocational colleges must keep pace with the times. While enhancing their own construction and effective utilization, it is crucial to explore implementation strategies from a new perspective of school-enterprise cooperation to achieve the core goal of higher vocational education, that is, to cultivate high-quality technical and skilled talents. This paper proposes strategies for construction and effective utilization from aspects such as building a deeply integrated school-enterprise cooperation mechanism, optimizing the planning and layout of bases, improving the management system of practical teaching and strengthening the construction of “dual-qualified” teacher teams, and promoting the dynamic adaptation of practical training content to industrial demands, aiming to cultivate and enhance students’ comprehensive skills and qualities through these practical bases, thereby continuously boosting their employment competitiveness and ultimately improving the quality of talent cultivation and education.