With the deepening advancement of the Belt and Road Initiative, cooperation between China and Southeast Asian countries has become increasingly close and frequent, and Sino-Thai cooperation has also been continuously deepened. Guided by this background, the social demand for Thai language talents is growing rapidly, especially in fields such as tourism, economy and trade, and cultural exchanges. Professional talents with Thai application capabilities are gradually gaining attention. Therefore, current applied universities need to target the talent needs in regional economic development to improve the classroom teaching quality of “College Foreign Language (Thai)” in the talent training process, thereby continuously enhancing students’ language practical ability and cross-cultural communication literacy. In addition, with the rapid development of the education field, the concept of the “New Three Centers” has gradually become the core guiding ideology for college teaching reform, exerting new impacts on the current teaching system and teaching model. Therefore, integrating the “New Three Centers” teaching concept into the teaching of “College Foreign Language (Thai)” in applied universities can help teachers better focus on student development and optimize the overall teaching effect.