For Generation Z, the rapid development of the social economy and internet information technology has brought unprecedented challenges to the physical and mental health of college students. Proper guidance on life outlook and life values plays a crucial role in college students’ personal development, mental health, and social adaptability. This paper points out the significant value of life education in enhancing the sense of life value, improving life quality, and promoting social harmony. It analyzes the practical dilemmas faced in life education practice, such as the gap between theoretical research and practical application, insufficient support for life education in the existing education system, and college students’ weak awareness of life. Based on the goals and content of life education, it explores specific educational practice paths, including curriculum design, teacher team building, campus culture construction, home-school-community collaboration, and the application of modern technology, to create comprehensive and multi-dimensional life education. The aim is to help college students establish a correct outlook on life, enhance life value, lay a solid foundation for future development, and promote social harmony.