The ongoing in-depth implementation of digital transformation in education offers a new path and opportunity for improving university laboratory safety control systems. In the current era, three main security risks exist in university laboratories. First, the inadequate implementation of system norms makes it difficult to address security risks. Second, safety education is insufficient, with both teachers and students lacking essential safety knowledge and skills. Third, safety facilities are incomplete, leading to an unstable safety foundation. To address these issues, this article proposes the establishment of a “three-combination” laboratory safety control system, based on a digital platform integrating management, education, and infrastructure. This approach utilizes the digital laboratory management platform to strengthen management practices, enhance safety education, improve environmental conditions, and effectively reduce laboratory safety risks. Lastly, the paper provides a brief overview of the practical implementation and outcomes of the digital laboratory safety control system in schools.