As a core course for nursing majors, Internal Medicine Nursing mainly covers basic medical knowledge and key nursing points for common internal medicine diseases. It is characterized by complicated knowledge points and a strong interdisciplinary nature. Under the traditional teaching mode, students find it difficult to understand the internal relations and logic among knowledge points, which is not conducive to constructing a systematic knowledge system and improving clinical application ability. As a visual knowledge organization tool, a knowledge graph can transform complex concepts into visual symbols, effectively integrate scattered knowledge points and clarify knowledge connections. On this basis, starting from the main functions of constructing a knowledge graph for the Internal Medicine Nursing course, this paper discusses its specific application paths, so as to provide a theoretical reference for improving the teaching quality of the course and realizing teaching reform.