With the accelerated informatization and digital transformation of higher education, the flipped classroom, as a student-centered teaching paradigm, provides important ideas for the innovation of ESP (English for Specific Purposes) teaching and the improvement of students’ classroom participation. This paper expounds on the compatibility between the flipped classroom and ESP teaching. Using literature review and induction methods, it explores the positive impacts of flipped classroom-based ESP teaching on learners’ classroom participation from three dimensions: participation motivation, participation depth, and participation scope. Furthermore, it puts forward optimization suggestions for ESP teaching, aiming to provide theoretical support and practical references for meeting students’ diverse learning needs, enhancing classroom participation, and improving the quality of ESP teaching.